Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.71 |
| ▸ | VEGFA | P15692 | 6/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273704 | 0.83 | EGLN1 (1.00) | EGLN1VEGFAKDM4EPOLBMAPT | |
| SCHEMBL272502 | 0.69 | EGLN1 (0.71) | EGLN1VEGFAKDM4EPOLBBRD4 | |
| SCHEMBL9965802 | 0.67 | MEN1 (0.64) | EGLN1VEGFAKDM4EMAPTMEN1 | |
| SCHEMBL12669231 | 0.67 | EGLN1 (0.72) | EGLN1VEGFAKDM4EHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4349681 | 0.66 | MEN1 (0.61) | EGLN1VEGFAKDM4EMAPTMEN1 | |
| SCHEMBL272670 | 0.66 | EGLN1 (0.88) | EGLN1VEGFAKDM4EPOLBALDH1A1 | |
| SCHEMBL20695802 | 0.65 | CHRM2 (0.50) | EGLN1VEGFAKDM4E | |
| SCHEMBL19157494 | 0.64 | EGLN1 (0.65) | EGLN1VEGFAKDM4EPOLBBRD4 | |
| SCHEMBL272319 | 0.63 | VEGFA (0.75) | EGLN1VEGFAMAPTMEN1HTT | |
| SCHEMBL12599456 | 0.63 | EGLN1 (0.80) | EGLN1VEGFAKDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2954899-A1 | COMPOSITIONS AND METHODS FOR TREATING COLITIS | Aerpio Therapeutics, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |