Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865337 | 0.79 | TLR9 (0.33) | L3MBTL1SMN1; SMN2ALDH1A1PTGER1KDM4E | |
| SCHEMBL20975343 | 0.77 | FFAR1 (0.37) | FFAR1MRGPRX4SGMS2NPC1RAB9A | |
| SCHEMBL19607323 | 0.77 | CYP19A1 (0.36) | MAPTSMN1; SMN2ALDH1A1PTGER1KDM4E | |
| SCHEMBL12154963 | 0.77 | L3MBTL1 (0.34) | FFAR1MRGPRX4L3MBTL1NPC1MAPT | |
| SCHEMBL15286185 | 0.76 | NPSR1 (0.36) | FFAR1MRGPRX4L3MBTL1NPC1MAPT | |
| SCHEMBL13311249 | 0.76 | L3MBTL1 (0.37) | MRGPRX4L3MBTL1MAPTSMN1; SMN2PTGER1 | |
| SCHEMBL14502597 | 0.75 | GLRA1 (0.35) | FFAR1MRGPRX4L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL6324123 | 0.74 | L3MBTL1 (0.40) | FFAR1MRGPRX4L3MBTL1ALDH1A1PTGER1 | |
| SCHEMBL4603257 | 0.74 | MRGPRX4 (0.40) | FFAR1MRGPRX4L3MBTL1NPC1MAPT | |
| SCHEMBL16507355 | 0.72 | MRGPRX4 (0.34) | FFAR1MRGPRX4L3MBTL1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461117-B2 | Chemical linkers and cleavable substrates and conjugates thereof | MEDAREX, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| EP-1940789-B1 | METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS | MEDAREX INC (US) | 2011-11-23 | — | — | EP | disclosed |
| US-7847105-B2 | Methods and compounds for preparing CC-1065 analogs | MEDAREX, INC. (US) | 2010-12-07 | — | — | US | disclosed |
| US-20100145036-A1 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | MEDAREX, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20080281102-A1 | Methods and Compounds For Preparing Cc-1065 Analogs | MEDAREX, INC. (US) | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080281102-A1 | Methods and Compounds For Preparing Cc-1065 Analogs | CCNI, CBR3, CNR1 | FFAR1 2199/4885MRGPRX4 981/4885MAPK14 2936/4885 |
| US-20100145036-A1 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | XIAP, ADAM8, CLSPN | FFAR1 3966/4885MRGPRX4 2737/4885MAPK14 3564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.