Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8132061 | 0.76 | MRGPRX4 (0.40) | MRGPRX4SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL1734375 | 0.74 | MRGPRX4 (0.43) | MRGPRX4SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8131442 | 0.74 | MRGPRX4 (0.39) | MRGPRX4SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL1734374 | 0.74 | FFAR1 (0.37) | MRGPRX4SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8141180 | 0.73 | MRGPRX4 (0.38) | MRGPRX4SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8135590 | 0.73 | TSPO (0.43) | MRGPRX4SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL12154966 | 0.71 | L3MBTL1 (0.34) | MRGPRX4SMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL13311249 | 0.69 | L3MBTL1 (0.37) | MRGPRX4SMN1; SMN2MAPTL3MBTL1PTGER1 | |
| SCHEMBL6959477 | 0.67 | MRGPRX4 (0.66) | MRGPRX4SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL30696120 | 0.67 | MRGPRX4 (0.66) | MRGPRX4SMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940789-A1 | METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS | Medarex, Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007051081-A1 | METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS | MEDAREX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |