Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29464052 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1GAAMAPTMEN1 | |
| SCHEMBL8566128 | 0.84 | BACE1 (0.39) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL8566129 | 0.84 | BACE1 (0.39) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL8566125 | 0.84 | BACE1 (0.39) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL550205 | 0.81 | KCNH2 (0.47) | KDM4EALDH1A1MAPTRAB9ACYP1A2 | |
| SCHEMBL8564051 | 0.81 | KCNH2 (0.47) | KDM4EALDH1A1MAPTRAB9ACYP1A2 | |
| SCHEMBL1184927 | 0.81 | ALDH1A1 (0.55) | KDM4EALDH1A1GAAMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL550146 | 0.80 | KCNH2 (0.46) | KDM4EALDH1A1MAPTRAB9ACYP1A2 | |
| SCHEMBL16772300 | 0.79 | MTNR1A (0.38) | KDM4EALDH1A1GAAMAPTMEN1 | |
| SCHEMBL3830913 | 0.77 | ALDH1A1 (0.45) | KDM4EALDH1A1GAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137419-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2017-05-18 | — | — | US | disclosed |
| US-20170137419-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2017-05-18 | — | — | US | disclosed |
| WO-2015189523-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | UNIVERSITE DU DROIT ET DE LA SANTE LILLE 2 (FR) | 2015-12-17 | — | — | WO | disclosed |
| CN-86103954-A | Preparation has the method for quinolone carboxylic acid ester's class of anti-microbial activity | — | 1987-01-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137419-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | CYP3A43, CYP3A5, CYP2D6 | KDM4E 3110/4885ALDH1A1 286/4885GAA 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.