Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566128 | 1.00 | BACE1 (0.39) | BACE1ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL8566125 | 1.00 | BACE1 (0.39) | BACE1ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL17348461 | 0.84 | KDM4E (0.50) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL16772300 | 0.83 | MTNR1A (0.38) | ALDH1A1KDM4EHPGDHSD17B10EPHX2 | |
| SCHEMBL3830913 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPTKCNH2LMNA | |
| SCHEMBL6629846 | 0.80 | KCNH2 (0.50) | BACE1ALDH1A1EPHX2MAPTKCNH2 | |
| Hydrochloric Acid SCHEMBL9046996 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTKCNH2LMNA | |
| SCHEMBL444604 | 0.80 | LMNA (0.38) | ALDH1A1KDM4EHSD17B10MAPTKCNH2 | |
| Hydrochloric Acid SCHEMBL2258244 | 0.78 | KCNH2 (0.49) | BACE1ALDH1A1EPHX2MAPTKCNH2 | |
| Hydrazine SCHEMBL27885781 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |