Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 7/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 7/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | CCND2 | P30279 | 2/20 | 0.42 |
| ▸ | CCND3 | P30281 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735388 | 0.87 | HRH3 (0.52) | RIPK2NOD2CDK4CCND1CCND2 | |
| SCHEMBL1735394 | 0.86 | RIPK2 (0.43) | RIPK2NOD2CDK4CCND1CCND2 | |
| SCHEMBL1734211 | 0.86 | RARA (0.52) | RIPK2NOD2CDK4CCND1CCND2 | |
| SCHEMBL1735193 | 0.83 | RIPK2 (0.43) | RIPK2NOD2CDK4CCND1CCND2 | |
| SCHEMBL1735356 | 0.78 | RIPK2 (0.49) | RIPK2NOD2CDK4CCND1CCND2 | |
| SCHEMBL1735231 | 0.76 | HRH3 (0.45) | RIPK2NOD2CDK4CCND1CCND2 | |
| SCHEMBL1736459 | 0.76 | RIPK2 (0.48) | RIPK2NOD2CDK4CCND1CCND2 | |
| SCHEMBL4462748 | 0.76 | HRH3 (0.49) | RIPK2NOD2CDK4CCND1CCND2 | |
| SCHEMBL1736410 | 0.76 | RIPK2 (0.51) | RIPK2NOD2CDK4CCND1CCND2 | |
| SCHEMBL1734235 | 0.75 | RIPK2 (0.43) | RIPK2NOD2CDK4CCND1CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | claimed |
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | disclosed |