Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735359 | 0.87 | OPRM1 (0.46) | HRH3HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL13605477 | 0.86 | SPHK2 (0.45) | HRH3SPHK2SPHK1CDK1KDR | |
| Hydrochloric Acid SCHEMBL1734487 | 0.86 | OPRM1 (0.45) | HRH3HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL13605464 | 0.85 | SPHK2 (0.46) | HRH3SPHK2SPHK1CDK1KDR | |
| SCHEMBL13605487 | 0.85 | DRD3 (0.44) | CDK1KDRHDAC3HDAC1HDAC2 | |
| SCHEMBL1735427 | 0.83 | DGAT1 (0.51) | HRH3SPHK2SPHK1DGAT1 | |
| SCHEMBL1736426 | 0.83 | DGAT1 (0.51) | HRH3SPHK2SPHK1DGAT1 | |
| SCHEMBL1735308 | 0.82 | DRD3 (0.51) | — | |
| SCHEMBL1735305 | 0.82 | DRD3 (0.51) | — | |
| SCHEMBL1734153 | 0.81 | CACNA1G (0.45) | HRH3CDK1KDRHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | claimed |