Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734611 | 0.90 | ALDH1A1 (0.52) | KDM4EALDH1A1SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL1734521 | 0.83 | HRH1 (0.52) | KDM4EALDH1A1SMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL1734127 | 0.80 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL1735729 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2VCPPOLB | |
| SCHEMBL1733447 | 0.79 | VCP (0.48) | KDM4EALDH1A1SMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL1734608 | 0.78 | ALDH1A1 (0.55) | KDM4EALDH1A1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL1734508 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1VCPHSD17B10HTT | |
| SCHEMBL1734267 | 0.77 | PIK3CB (0.57) | KDM4EALDH1A1SMN1; SMN2ADORA2AVCP | |
| SCHEMBL1734332 | 0.77 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL1734504 | 0.77 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891018-B1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2011-11-16 | — | — | EP | claimed |
| WO-2011131686-A1 | A THERMALLY CONTROLLED ASSEMBLY | NAPATECH A/S (DK) | 2011-10-27 | — | — | WO | claimed |