Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 4/20 | 0.40 |
| ▸ | CASR | P41180 | 5/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | LOX | P28300 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15832232 | 0.81 | AR (0.46) | ARGRIN1GRIN2BRXRAIDH1 | |
| SCHEMBL23368131 | 0.81 | ELOVL1 (0.40) | GRIN1GRIN2BRXRACASRLOXL2 | |
| SCHEMBL17356151 | 0.79 | ELOVL1 (0.39) | GRIN1GRIN2BRXRACASR | |
| SCHEMBL17356160 | 0.79 | CASR (0.38) | IDH1CASRCYP3A4CYP2D6TSHR | |
| SCHEMBL15825104 | 0.78 | AR (0.43) | ARGRIN1GRIN2BRXRAIDH1 | |
| SCHEMBL21887849 | 0.78 | ELOVL1 (0.38) | CASR | |
| SCHEMBL21805818 | 0.78 | CASR (0.34) | GRIN1GRIN2BRXRAIDH1CASR | |
| SCHEMBL20242016 | 0.78 | AR (0.43) | ARGRIN1GRIN2BRXRAIDH1 | |
| SCHEMBL19068634 | 0.77 | AR (0.43) | ARGRIN1GRIN2BRXRALOXL2 | |
| SCHEMBL17356165 | 0.74 | CASR (0.41) | ARGRIN1GRIN2BRXRACASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695198-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150368269-A1 | Factor IXa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368269-A1 | Factor IXa Inhibitors | F9, TFPI, F13B | AR 3120/4885GRIN1 4819/4885GRIN2B 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.