Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5751012 | 0.83 | PTPN1 (0.33) | — | |
| SCHEMBL17358644 | 0.78 | GLA (0.33) | POLBLMNAMAPTKMT2AL3MBTL1 | |
| SCHEMBL21278251 | 0.77 | — | — | |
| SCHEMBL22334236 | 0.74 | POLB (0.30) | POLB | |
| SCHEMBL18995443 | 0.59 | POLB (0.36) | POLBLMNAMAPTKMT2AL3MBTL1 | |
| SCHEMBL25529234 | 0.59 | — | — | |
| SCHEMBL16174779 | 0.58 | PTPN1 (0.34) | — | |
| SCHEMBL2710911 | 0.56 | PTPN1 (0.40) | LMNA | |
| SCHEMBL16174752 | 0.56 | PTPN1 (0.36) | LMNA | |
| SCHEMBL21415445 | 0.55 | PTPN1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975096-B2 | Synthesis of polycyclic-carbamoylpyridone compounds | GILEAD SCIENCES, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20200223866-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2020-07-16 | — | — | US | disclosed |
| US-20180022757-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2018-01-25 | — | — | US | disclosed |
| US-20150368264-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2015-12-24 | — | — | US | disclosed |
| US-20150368264-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2015-12-24 | — | — | US | disclosed |
| WO-2015195656-A2 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES ,INC. (US) | 2015-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368264-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | POLB 783/4885LMNA 2030/4885MAPT 3114/4885 |
| US-20200223866-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | POLB 783/4885LMNA 2030/4885MAPT 3114/4885 |
| US-20180022757-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | POLB 783/4885LMNA 2030/4885MAPT 3114/4885 |
| US-10975096-B2 | Synthesis of polycyclic-carbamoylpyridone compounds | CPS1, SDHA, DHPS | POLB 783/4885LMNA 2030/4885MAPT 3114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.