⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15937215 | 0.94 | GRIN2B (0.32) | — | |
| SCHEMBL15937177 | 0.94 | GRIN2B (0.32) | — | |
| SCHEMBL19129082 | 0.92 | JAK3 (0.33) | — | |
| SCHEMBL17359167 | 0.87 | — | — | |
| SCHEMBL15937172 | 0.86 | JAK3 (0.33) | — | |
| SCHEMBL17359172 | 0.86 | JAK3 (0.33) | — | |
| SCHEMBL17359193 | 0.85 | ALDH1A1 (0.35) | — | |
| SCHEMBL17359169 | 0.84 | CTSK (0.32) | — | |
| SCHEMBL17359171 | 0.83 | GRIN2B (0.47) | — | |
| SCHEMBL17351832 | 0.83 | GRIN2B (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127430-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2018-05-10 | — | — | US | disclosed |
| US-9708335-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | Apytinyx Inc. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150368254-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2015-12-24 | — | — | US | disclosed |