SCHEMBL17360640

SCHEMBL17360640

CC(=O)Oc1coc(-c2ccc3ccccc3c2)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.54
HDAC8 Q9BY41 2/20 0.54
HDAC6 Q9UBN7 2/20 0.54
ALDH1A1 P00352 4/20 0.46
HPGD P15428 2/20 0.46
LMNA P02545 2/20 0.46
MAPT P10636 2/20 0.46
KDM4E B2RXH2 2/20 0.46
UTRN P46939 2/20 0.43
CYP1A2 P05177 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
HSD17B10 Q99714 2/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
TSHR P16473 1/20 0.41
NOTUM Q6P988 1/20 0.40
ERO1A Q96HE7 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
SLC6A3 Q01959 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27521361 0.83 HDAC6 (0.49) HDAC1HDAC8HDAC6ALDH1A1HPGD
SCHEMBL4640428 0.80 MAPK1 (0.47) ALDH1A1HPGDLMNAMAPTKDM4E
SCHEMBL27516569 0.78 LMNA (0.53) HDAC1HDAC8HDAC6ALDH1A1LMNA
SCHEMBL27539135 0.77 LMNA (0.40) HDAC1HDAC8HDAC6ALDH1A1HPGD
SCHEMBL4639858 0.76 S1PR1 (0.47) ALDH1A1HPGDLMNAMAPTKDM4E
SCHEMBL12521272 0.74 HDAC1 (0.72) HDAC1HDAC8HDAC6ALDH1A1KDM4E
SCHEMBL6242526 0.72 LMNA (0.59) ALDH1A1HPGDLMNAMAPTHSD17B10
SCHEMBL14266177 0.72 SMN1; SMN2 (0.54) HDAC1HDAC8HDAC6ALDH1A1HPGD
SCHEMBL5117052 0.70 HDAC1 (0.56) HDAC1HDAC8HDAC6ALDH1A1LMNA
SCHEMBL27521358 0.70 HDAC1 (0.49) HDAC1HDAC8HDAC6ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2959918-B1 ANTI-MALIGNANT TUMOR AGENT COMPOSITION J PHARMA CO LTD (JP) 2019-05-22 EP disclosed
EP-2959918-A1 ANTI-MALIGNANT TUMOR AGENT COMPOSITION J-Pharma Co., Ltd. (JP) 2015-12-30 EP disclosed