SCHEMBL1736407

SCHEMBL1736407

CC(=O)C(=O)OC(=O)C=Cc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
KMT2A Q03164 4/20 0.55
MAPT P10636 7/20 0.52
ALDH1A1 P00352 5/20 0.52
LMNA P02545 4/20 0.52
HDAC3 O15379 2/20 0.52
HDAC4 P56524 2/20 0.52
HDAC1 Q13547 2/20 0.52
HDAC2 Q92769 2/20 0.52
HDAC8 Q9BY41 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
PLIN1 O60240 2/20 0.52
RECQL P46063 2/20 0.52
PLIN5 Q00G26 2/20 0.52
ABHD5 Q8WTS1 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
TNKS O95271 1/20 0.52
HCAR2 Q8TDS4 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1736406 1.00 GLA (0.58) GLATDP1KMT2AMAPTALDH1A1
SCHEMBL29198288 0.89 MAPT (0.59) GLATDP1KMT2AMAPTALDH1A1
SCHEMBL10760753 0.86 GLA (0.55) GLATDP1KMT2AMAPTALDH1A1
SCHEMBL4122409 0.86 GLA (0.55) GLATDP1KMT2AMAPTALDH1A1
SCHEMBL6036031 0.85 GLA (0.62) GLATDP1KMT2AMAPTALDH1A1
SCHEMBL6036032 0.85 GLA (0.62) GLATDP1KMT2AMAPTALDH1A1
SCHEMBL775716 0.85 MAPT (0.64) GLATDP1KMT2AMAPTALDH1A1
SCHEMBL21803794 0.85 MAPT (0.64) GLATDP1KMT2AMAPTALDH1A1
SCHEMBL9247555 0.85 MAPT (0.64) GLATDP1KMT2AMAPTALDH1A1
SCHEMBL1721581 0.84 GLA (0.60) GLATDP1KMT2AMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7186416-B2 Foamable pharmaceutical compositions and methods for treating a disorder STIEFEL LABORATORIES, INC. (US) 2007-03-06 US claimed
EP-1067896-B1 TOPICAL COMPOSITIONS COMPRISING ASCORBYL-PHOSPHORYL-CHOLESTEROL AVON PROD INC (US) 2005-07-27 EP claimed
US-9827195-B2 Fatty acid pharmaceutical foam STIEFEL RESEARCH AUSTRALIA PTY LTD (AU) 2017-11-28 US disclosed
US-20150209280-A1 FATTY ACID PHARMACEUTICAL FOAM STIEFEL RES AUSTRALIA PTY LTD (AU) 2015-07-30 US disclosed
US-9023863-B2 Fatty acid pharmaceutical foam STIEFEL RESEARCH AUSTRALIA PTY LTD (AU) 2015-05-05 US disclosed
EP-2046121-B1 FATTY ACID PHARMACEUTICAL FOAM STIEFEL RES AUSTRALIA PTY LTD (AU) 2012-08-22 EP disclosed
EP-1633368-B1 FOAMABLE PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING A DISORDER STIEFEL LABORATORIES (US) 2011-11-16 EP disclosed
WO-2011066182-A3 SOCS3 INHIBITION PROMOTES CNS NEURON REGENERATION CHILDREN'S MEDICAL CENTER CORPORATION (US) 2011-10-27 WO disclosed
US-7829107-B2 Foamable pharmaceutical compositions and methods for treating a disorder STIEFEL LABORATORIES, INC. (US) 2010-11-09 US disclosed
EP-2046121-A2 FATTY ACID PHARMACEUTICAL FOAM Stiefel Research Australia Pty Ltd (AU) 2009-04-15 EP disclosed
WO-2008008397-A2 FATTY ACID PHARMACEUTICAL FOAM STIEFEL RESEARCH AUSTRALIA PTY LTD (AU) 2008-01-17 WO disclosed
US-20050232957-A1 Compositions and methods for moisturizing skin TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE 2005-10-20 US disclosed
WO-2004105702-A2 FOAMABLE PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING A DISORDER STIEFEL LABORATORIES, INC. (US) 2004-12-09 WO disclosed
US-20040241099-A1 Foamable pharmaceutical compositions and methods for treating a disorder CONNETICS CORPORATION 2004-12-02 US disclosed
US-20040120990-A1 Absorbent proteins and methods for using same CUSHMAN JOHN C (US) 2004-06-24 US disclosed
EP-1324681-A2 ARTICLE FOR THE DELIVERY OF FOAM PRODUCTS THE PROCTER & GAMBLE COMPANY (US) 2003-07-09 EP disclosed
US-6547063-B1 Article for the delivery of foam products THE PROCTER & GAMBLE COMPANY 2003-04-15 US disclosed
WO-2002030237-A2 ARTICLE FOR THE DELIVERY OF FOAM PRODUCTS THE PROCTER & GAMBLE COMPANY (US) 2002-04-18 WO disclosed
US-6283336-B1 Article for the delivery of foam products THE PROCTER & GAMBLE COMPANY 2001-09-04 US disclosed
US-5629301-A Use of salicylic acid for regulating skin wrinkles and/or skin atrophy RICHARDSON-VICKS INC. (US) 1997-05-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150209280-A1 FATTY ACID PHARMACEUTICAL FOAM FASN, FFAR3, FFAR1 GLA 1170/4885TDP1 1111/4885KMT2A 4288/4885
US-20040241099-A1 Foamable pharmaceutical compositions and methods for treating a disorder CLN6, CYP27A1, CYP46A1 GLA 1711/4885TDP1 533/4885KMT2A 4718/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.