Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17365660 | 0.84 | POLB (0.63) | POLBCYP2C19MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5511513 | 0.84 | POLB (0.57) | POLBMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL16244497 | 0.81 | POLB (0.48) | POLBCYP2C19MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL230178 | 0.77 | POLB (0.60) | POLBCYP2C19MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19318513 | 0.76 | POLB (0.59) | POLBCYP2C19MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5509028 | 0.75 | POLB (0.55) | POLBMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL14200371 | 0.74 | OPRM1 (0.48) | POLBCYP2C19MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7794443 | 0.74 | POLB (0.57) | POLBCYP2C19MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5508940 | 0.74 | POLB (0.60) | POLBMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL14543473 | 0.72 | OPRM1 (0.47) | POLBMEN1KMT2ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221821-B2 | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds | Forest Laboratories Holdings, Limited (BM) | 2015-12-29 | — | — | US | disclosed |