Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EEF2K | O00418 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | EEF2 | P13639 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.31 |
| ▸ | HTR3B | O95264 | 2/20 | 0.31 |
| ▸ | HTR3A | P46098 | 2/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331175 | 0.83 | LMNA (0.53) | LMNASMN1; SMN2HPGDPDE4APDE4B | |
| SCHEMBL240142 | 0.78 | LMNA (0.51) | LMNASMN1; SMN2HPGDPDE4APDE4B | |
| SCHEMBL2756837 | 0.78 | LMNA (0.51) | LMNASMN1; SMN2HPGDPDE4APDE4B | |
| SCHEMBL1546067 | 0.76 | LMNA (0.55) | LMNASMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL2332943 | 0.75 | LMNA (0.51) | LMNASMN1; SMN2HPGDPDE4APDE4B | |
| SCHEMBL1108630 | 0.73 | EEF2K (0.51) | EEF2KHPGDNPC1RAB9AEEF2 | |
| SCHEMBL2333544 | 0.71 | LMNA (0.52) | LMNASMN1; SMN2HPGDPDE5APDE4A | |
| SCHEMBL1546570 | 0.71 | PDE5A (0.46) | LMNASMN1; SMN2HPGDPDE5APDE4A | |
| SCHEMBL14016193 | 0.71 | LMNA (0.76) | LMNASMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL4639746 | 0.70 | LMNA (0.49) | LMNASMN1; SMN2HPGDPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221821-B2 | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds | Forest Laboratories Holdings, Limited (BM) | 2015-12-29 | — | — | US | disclosed |
| US-9221821-B2 | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds | Forest Laboratories Holdings, Limited (BM) | 2015-12-29 | — | — | US | disclosed |