Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 2/20 | 0.51 |
| ▸ | EEF2 | P13639 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.36 |
| ▸ | HTR3B | O95264 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108631 | 0.88 | EEF2K (0.48) | EEF2KEEF2NPC1RAB9AALDH1A1 | |
| SCHEMBL28863512 | 0.78 | HPGD (0.41) | EEF2KEEF2ALDH1A1CYP3A4DRD2 | |
| SCHEMBL2330664 | 0.78 | ALDH1A1 (0.47) | ALDH1A1CYP3A4PDE4APDE4BPDE4C | |
| SCHEMBL6305749 | 0.76 | ALDH1A1 (0.64) | ALDH1A1CYP3A4PDE4APDE4BPDE4C | |
| SCHEMBL1108635 | 0.76 | EEF2K (0.46) | EEF2KEEF2NPC1RAB9AALDH1A1 | |
| SCHEMBL9427221 | 0.76 | PIK3CA (0.35) | EEF2KEEF2ALDH1A1CYP3A4PIK3CA | |
| SCHEMBL30951218 | 0.75 | CYP3A4 (0.61) | ALDH1A1CYP3A4HTR3EHTR3BHTR3A | |
| SCHEMBL7776460 | 0.74 | PDE5A (0.45) | ALDH1A1CYP3A4CTSKPDE5APDE4A | |
| SCHEMBL12090565 | 0.73 | EEF2K (0.49) | EEF2KEEF2ALDH1A1CTSKPDE5A | |
| SCHEMBL17364392 | 0.73 | LMNA (0.46) | EEF2KEEF2NPC1RAB9ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221821-B2 | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds | Forest Laboratories Holdings, Limited (BM) | 2015-12-29 | — | — | US | disclosed |
| US-9221821-B2 | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds | Forest Laboratories Holdings, Limited (BM) | 2015-12-29 | — | — | US | disclosed |
| US-8501941-B2 | Methods for the synthesis of unsymmetrical cycloakyl substituted xanthines | DOGWOOD PHARMACEUTICALS, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501941-B2 | Methods for the synthesis of unsymmetrical cycloakyl substituted xanthines | DOGWOOD PHARMACEUTICALS, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8420813-B2 | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines | DOGWOOD PHARMACEUTICALS, INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-8420813-B2 | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines | DOGWOOD PHARMACEUTICALS, INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-20120226040-A1 | METHODS FOR THE SYNTHESIS OF UNSYMMETRICAL CYCLOAKYL SUBSTITUTED XANTHINES | DOGWOOD PHARMACEUTICALS, INC. (US) | 2012-09-06 | — | — | US | disclosed |
| US-20120226040-A1 | METHODS FOR THE SYNTHESIS OF UNSYMMETRICAL CYCLOAKYL SUBSTITUTED XANTHINES | DOGWOOD PHARMACEUTICALS, INC. (US) | 2012-09-06 | — | — | US | disclosed |
| US-8153628-B2 | Pyrazolyl substituted xanthines | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2012-04-10 | — | — | US | disclosed |
| US-8153628-B2 | Pyrazolyl substituted xanthines | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2012-04-10 | — | — | US | disclosed |
| US-7601723-B2 | Pyridyl substituted xanthines | PGX HEALTH, LLC (US) | 2009-10-13 | — | — | US | disclosed |
| US-7598379-B2 | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines | PGX HEALTH, LLC (US) | 2009-10-06 | — | — | US | disclosed |
| US-7598379-B2 | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines | PGX HEALTH, LLC (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070105821-A1 | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines | ALLERGAN SALES, LLC | 2007-05-10 | — | — | US | disclosed |
| US-20070105821-A1 | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines | ALLERGAN SALES, LLC | 2007-05-10 | — | — | US | disclosed |
| US-20070072843-A1 | For treating asthma and improving insulin sensitivity | ADENOSINE THERAPEUTICS, LLC | 2007-03-29 | — | — | US | disclosed |
| US-20070072843-A1 | For treating asthma and improving insulin sensitivity | ADENOSINE THERAPEUTICS, LLC | 2007-03-29 | — | — | US | disclosed |
| US-20070066631-A1 | Pyrazolyl substituted xanthines | ADENOSINE THERAPEUTICS, LLC | 2007-03-22 | — | — | US | disclosed |
| US-20070049757-A1 | Methods for the synthesis of substituted amino uracils | ADENOSINE THERAPEUTICS, LLC | 2007-03-01 | — | — | US | disclosed |
| US-20070049757-A1 | Methods for the synthesis of substituted amino uracils | ADENOSINE THERAPEUTICS, LLC | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066631-A1 | Pyrazolyl substituted xanthines | ADORA2B, ADORA2A, ADORA3 | EEF2K 2793/4885EEF2 4064/4885NPC1 1223/4885 |
| US-20120226040-A1 | METHODS FOR THE SYNTHESIS OF UNSYMMETRICAL CYCLOAKYL SUBSTITUTED XANTHINES | ADORA2B, ADORA2A, ADORA3 | EEF2K 1679/4885EEF2 3391/4885NPC1 2226/4885 |
| US-20070105821-A1 | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines | ADORA2B, ADORA2A, ADORA3 | EEF2K 2606/4885EEF2 3342/4885NPC1 1510/4885 |
| US-20070049757-A1 | Methods for the synthesis of substituted amino uracils | UNG, UMPS, NUDT1 | EEF2K 1788/4885EEF2 1285/4885NPC1 4011/4885 |
| US-20070072843-A1 | For treating asthma and improving insulin sensitivity | ADORA2B, GPR119, ADORA2A | EEF2K 1540/4885EEF2 2796/4885NPC1 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.