Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 7/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735361 | 0.90 | OPRM1 (0.44) | HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL1735235 | 0.89 | LTA4H (0.52) | KCNA5KMT2ADRD3MCHR1JAK2 | |
| SCHEMBL14177214 | 0.87 | KCNA5 (0.47) | KCNA5KMT2ADRD3MCHR1JAK2 | |
| SCHEMBL13605282 | 0.86 | PRKDC (0.48) | KCNA5DRD3MCHR1JAK2JAK3 | |
| SCHEMBL13605326 | 0.86 | MCHR1 (0.55) | KCNA5DRD3MCHR1JAK2JAK3 | |
| SCHEMBL1735370 | 0.84 | JAK2 (0.44) | MCHR1JAK2JAK3HDAC1HDAC6 | |
| SCHEMBL1735396 | 0.84 | KCNH2 (0.55) | KMT2AJAK2JAK3HDAC1HDAC6 | |
| SCHEMBL13605293 | 0.83 | MCHR1 (0.61) | MCHR1JAK2JAK3HDAC1HDAC6 | |
| SCHEMBL13605387 | 0.83 | DRD3 (0.68) | KCNA5DRD3DRD2HRH2HRH1 | |
| SCHEMBL13605385 | 0.82 | MCHR1 (0.52) | KCNA5DRD3MCHR1BRAFRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | claimed |