Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 9/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17366161 | 0.85 | MDM2 (0.51) | MDM2TP53MEN1KMT2AKDM4E | |
| SCHEMBL17366153 | 0.84 | MDM2 (0.52) | MDM2TP53MEN1KMT2AKDM4E | |
| SCHEMBL30121977 | 0.76 | MDM2 (0.64) | MDM2TP53MEN1KMT2AKDM4E | |
| SCHEMBL17366172 | 0.75 | MDM2 (0.54) | MDM2TP53MEN1KMT2AKDM4E | |
| SCHEMBL31520186 | 0.74 | MDM2 (0.45) | MDM2TP53MEN1KMT2ARXFP1 | |
| SCHEMBL12332978 | 0.71 | MDM2 (0.53) | MDM2TP53MEN1KMT2A | |
| SCHEMBL17366169 | 0.71 | MDM2 (0.58) | MDM2TP53ALDH1A1HTTNPSR1 | |
| SCHEMBL17366174 | 0.71 | MDM2 (0.58) | MDM2TP53MEN1KMT2AKDM4E | |
| SCHEMBL17366151 | 0.71 | MDM2 (0.58) | MDM2TP53MEN1KMT2AKDM4E | |
| SCHEMBL17366177 | 0.71 | MEN1 (0.48) | MDM2TP53MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960233-B1 | NEW THERAPEUTIC AGENTS | CANCER RESEARCH TECH LTD (GB) | 2019-10-30 | — | — | EP | disclosed |
| EP-2960233-A1 | NEW THERAPEUTIC AGENTS | Cancer Research Technology Limited (GB) | 2015-12-30 | — | — | EP | disclosed |