SCHEMBL17366379

SCHEMBL17366379

CCOc1ccc(N(c2ccc(/C=C/C=N/N(c3ccccc3)c3ccccc3)cc2)c2ccc(/C=C/C=N/N(c3ccccc3)c3ccccc3)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RELA Q04206 1/20 0.54
MAPT P10636 4/20 0.47
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
KMT2A Q03164 3/20 0.47
GAA P10253 2/20 0.47
MEN1 O00255 2/20 0.47
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.45
MAOB P27338 2/20 0.41
MAOA P21397 1/20 0.41
ALOX5 P09917 1/20 0.41
TP53 P04637 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ESR1 P03372 2/20 0.40
AHR P35869 1/20 0.40
LTA4H P09960 1/20 0.40
EGFR P00533 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17366359 0.85 TLR4 (0.39) RELAMAPTNPC1RAB9AKMT2A
SCHEMBL17366378 0.84 MAPT (0.40) RELAMAPTNPC1RAB9AKMT2A
SCHEMBL17366374 0.84 GAA (0.52) RELAMAPTNPC1RAB9AKMT2A
SCHEMBL17366360 0.83 MAOB (0.45) RELAMAPTKMT2AMEN1KDM4E
SCHEMBL16604897 0.83 RELA (0.72) RELAMAPTNPC1RAB9AKMT2A
SCHEMBL10866111 0.83 RELA (0.77) RELAMAPTNPC1RAB9AKMT2A
SCHEMBL11033784 0.83 RELA (0.77) RELAMAPTNPC1RAB9AKMT2A
SCHEMBL8576278 0.79 GAA (0.56) RELAMAPTNPC1RAB9AKMT2A
SCHEMBL8576277 0.79 GAA (0.56) RELAMAPTNPC1RAB9AKMT2A
SCHEMBL23606864 0.79 RELA (0.60) RELAMAPTNPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2960229-B1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC (JP) 2017-02-15 EP disclosed
US-9454091-B2 Hydrazone derivative of triphenylamine and electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-09-27 US disclosed
US-9454091-B2 Hydrazone derivative of triphenylamine and electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-09-27 US disclosed
US-20150378269-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2015-12-31 US disclosed
US-20150378269-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2015-12-31 US disclosed
EP-2960229-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER Kyocera Document Solutions Inc. (JP) 2015-12-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150378269-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER NAT1, GSTA1, PKN1 RELA 2887/4885MAPT 3553/4885NPC1 1130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.