Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.52 |
| ▸ | KDM1A | O60341 | 5/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | LIPE | Q05469 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31473325 | 0.89 | KDM1A (0.46) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL171841 | 0.86 | MRGPRX4 (0.68) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL686650 | 0.84 | MAPT (0.58) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL14228414 | 0.82 | MAPT (0.56) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL28643177 | 0.82 | MRGPRX4 (0.49) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL18787264 | 0.81 | KDM1A (0.48) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL29703994 | 0.81 | KDM1A (0.48) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL26096078 | 0.81 | MAPT (0.51) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL23258544 | 0.81 | MRGPRX4 (0.58) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL28399722 | 0.81 | LMNA (0.52) | MAPTMAPK1TDP1L3MBTL1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9549927-B2 | Heteroaryl compounds and uses thereof | CELGENE AVILOMICS RESEARCH, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150374690-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE CAR LLC (BM) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150374690-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | MAPT 1888/4885MAPK1 4884/4885TDP1 2415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.