Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 4/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1736510 | 0.87 | NOTUM (0.41) | KMT2ANOTUMSMN1; SMN2MAPT | |
| SCHEMBL1734637 | 0.84 | MMP2 (0.49) | MEN1KMT2AALDH1A1MMP2ANPEP | |
| SCHEMBL1735684 | 0.84 | CTSS (0.41) | MEN1KMT2AALDH1A1RAB9AHSD17B10 | |
| SCHEMBL1735683 | 0.84 | CTSS (0.41) | MEN1KMT2AALDH1A1RAB9AHSD17B10 | |
| SCHEMBL1736744 | 0.83 | GAA (0.40) | MEN1KMT2AALDH1A1RAB9AHSD17B10 | |
| SCHEMBL1737333 | 0.78 | ACACB (0.38) | ALDH1A1RAB9AHSD17B10SMN1; SMN2POLB | |
| SCHEMBL1735657 | 0.74 | MAPT (0.44) | MEN1KMT2AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL1734754 | 0.71 | MCL1 (0.44) | MEN1KMT2AALDH1A1RAB9AMMP2 | |
| SCHEMBL1734756 | 0.71 | MCL1 (0.44) | MEN1KMT2AALDH1A1RAB9AMMP2 | |
| SCHEMBL1736975 | 0.70 | FAAH (0.44) | MEN1KMT2ACTSSNOTUML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142533-B1 | IMIDAZOLIDINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-11-16 | — | — | EP | disclosed |
| WO-2011069003-A3 | METHODS AND SYSTEMS FOR THE TREATMENT OF ANXIETY DISORDERS AND DISORDERS WITH PSYCHOTIC FEATURES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-10-27 | — | — | WO | disclosed |
| US-7625902-B2 | Imidazolidinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-20080242677-A1 | IMIDAZOLIDINONE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242677-A1 | IMIDAZOLIDINONE DERIVATIVES | NR1H2, NR1H3, NR1I2 | MEN1 2714/4885KMT2A 2144/4885ALDH1A1 1786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.