Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | ATAD2 | Q6PL18 | 7/20 | 0.48 |
| ▸ | CECR2 | Q9BXF3 | 7/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17367679 | 1.00 | TSHR (0.55) | TSHRLMNAHTTMAPK1HPGD | |
| SCHEMBL17367674 | 0.91 | TSHR (0.58) | TSHRLMNAHTTEPHX2ATAD2 | |
| SCHEMBL17367675 | 0.91 | LMNA (0.65) | TSHRLMNAHTTMAPK1HPGD | |
| SCHEMBL17014215 | 0.83 | CCR1 (0.58) | TSHRLMNAHTTMAPK1HPGD | |
| SCHEMBL15916783 | 0.82 | EPHX2 (0.50) | TSHRLMNAHTTMAPK1HPGD | |
| SCHEMBL15916137 | 0.82 | EPHX2 (0.53) | TSHRLMNAHTTMAPK1HPGD | |
| SCHEMBL15915662 | 0.82 | EPHX2 (0.50) | TSHRLMNAHTTMAPK1HPGD | |
| SCHEMBL2061899 | 0.82 | POLB (0.47) | TSHRLMNAHTTMAPK1HPGD | |
| SCHEMBL15915846 | 0.82 | EPHX2 (0.53) | TSHRLMNAHTTMAPK1HPGD | |
| SCHEMBL15915660 | 0.82 | EPHX2 (0.50) | TSHRLMNAHTTMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376212-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | TSHR 2884/4885LMNA 3880/4885HTT 4842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.