Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.53 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19285885 | 0.82 | ALOX5AP (0.52) | LMNAMCL1ALOX5APFEN1IDH1 | |
| SCHEMBL15915645 | 0.81 | ALOX5AP (0.46) | LMNAMCL1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL30994933 | 0.81 | ALOX5AP (0.46) | LMNAMCL1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL16021159 | 0.80 | MCL1 (0.47) | MCL1ALOX5APFEN1IDH1ALDH1A1 | |
| SCHEMBL27256998 | 0.79 | MCL1 (0.46) | LMNAMCL1IDH1KCNJ6KCNJ3 | |
| SCHEMBL3088227 | 0.79 | MCL1 (0.49) | LMNAMCL1IDH1ALDH1A1KCNJ6 | |
| SCHEMBL19285886 | 0.79 | ALDH1A1 (0.59) | LMNAMCL1ALOX5APFEN1IDH1 | |
| SCHEMBL4183675 | 0.78 | ALOX5AP (0.43) | LMNAMCL1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL13407614 | 0.78 | MCL1 (0.51) | LMNAMCL1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL2525525 | 0.77 | LMNA (0.65) | LMNAMCL1IDH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376212-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | LMNA 3880/4885MCL1 2515/4885ALOX5AP 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.