SCHEMBL1737284

SCHEMBL1737284

Cc1c(C)n(Cc2ccc(F)cc2)c2c(N3CCc4ccc(Cl)cc4C3C)nccc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
MAPT P10636 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
PDE1A P54750 1/20 0.32
PDE1B Q01064 1/20 0.32
PDE1C Q14123 1/20 0.32
TP53 P04637 1/20 0.32
OPRK1 P41145 1/20 0.32
PTGDR2 Q9Y5Y4 4/20 0.31
HRH4 Q9H3N8 1/20 0.31
PLA2G2A P14555 1/20 0.31
CCR1 P32246 1/20 0.31
CHI3L1 P36222 1/20 0.31
CHIT1 Q13231 1/20 0.31
CHIA Q9BZP6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1735604 0.99 CYP1A2 (0.35) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL1736826 0.94 CYP2D6 (0.37) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL1737551 0.93 PDE1B (0.34) CYP2C19MEN1KMT2APDE1APDE1B
Hydrochloric Acid SCHEMBL1737021 0.93 CYP2D6 (0.37) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL1738084 0.92 PDE1B (0.34) CYP2C19PDE1APDE1BPDE1CCHI3L1
SCHEMBL1737665 0.92 HTR6 (0.35) MAPTMEN1KMT2APDE1APDE1B
SCHEMBL1737976 0.91 FABP4 (0.39) MAPTMEN1KMT2APDE1APDE1B
Hydrochloric Acid SCHEMBL1737491 0.91 HTR6 (0.34) MAPTPDE1APDE1BPDE1CPTGDR2
SCHEMBL1737157 0.90 CYP1A2 (0.35) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL1738247 0.90 FABP4 (0.38) MAPTMEN1KMT2APDE1APDE1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed