SCHEMBL1737157

SCHEMBL1737157

Cc1ccc(Cn2c(C)c(C)c3ccnc(N4CCc5ccc(F)cc5C4C)c32)cc1

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
SCD O00767 1/20 0.33
PARP1 P09874 1/20 0.33
MCL1 Q07820 1/20 0.31
FABP4 P15090 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1737962 0.99 CYP1A2 (0.34) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL1736826 0.96 CYP2D6 (0.37) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL1737021 0.95 CYP2D6 (0.37) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL1739772 0.93 FABP4 (0.38) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL1738233 0.92 FABP4 (0.37) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL1736043 0.90 HTR6 (0.35) CYP1A2CYP3A4CYP2D6CYP2C19MEN1
SCHEMBL1737284 0.90 CYP1A2 (0.36) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL1737551 0.90 PDE1B (0.34) CYP2C19MEN1KMT2AMCL1FABP4
Hydrochloric Acid SCHEMBL1736873 0.90 HTR6 (0.34) CYP1A2CYP3A4CYP2D6CYP2C19MEN1
Hydrochloric Acid SCHEMBL1735604 0.90 CYP1A2 (0.35) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed
EP-1784404-A4 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2009-09-09 EP disclosed
EP-1784404-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Yuhan Corporation (KR) 2007-05-16 EP disclosed
WO-2006025716-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 WO disclosed