SCHEMBL1737488

SCHEMBL1737488

CCn1c(C)c(C)c2ccnc(COc3ccccc3Cl)c21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.39
TP53 P04637 2/20 0.38
ALDH1A1 P00352 4/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
PKM P14618 2/20 0.37
GAA P10253 1/20 0.37
CRHBP P24387 1/20 0.37
CRHR2 Q13324 1/20 0.37
FFAR1 O14842 1/20 0.37
MAPK1 P28482 4/20 0.36
MAPT P10636 3/20 0.36
CDC7 O00311 1/20 0.36
PLK4 O00444 1/20 0.36
DYRK3 O43781 1/20 0.36
ROCK2 O75116 1/20 0.36
MAP4K4 O95819 1/20 0.36
ROS1 P08922 1/20 0.36
PRKACA P17612 1/20 0.36
RPS6KB1 P23443 1/20 0.36
MARK3 P27448 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1738061 0.99 KDM4E (0.38) KDM4ETP53ALDH1A1SMN1; SMN2PKM
SCHEMBL1737420 0.91 KDM4E (0.37) KDM4EALDH1A1SMN1; SMN2PKMGAA
Hydrochloric Acid SCHEMBL1736963 0.90 KDM4E (0.37) KDM4EALDH1A1SMN1; SMN2PKMGAA
SCHEMBL1737165 0.88 FABP4 (0.44) KDM4ETP53ALDH1A1SMN1; SMN2MAPK1
Hydrochloric Acid SCHEMBL1737555 0.87 FABP4 (0.43) KDM4ETP53ALDH1A1SMN1; SMN2MAPK1
SCHEMBL1738542 0.86 MCL1 (0.40) KDM4ETP53ALDH1A1SMN1; SMN2MAPT
SCHEMBL1737357 0.86 MCL1 (0.40) KDM4ETP53ALDH1A1SMN1; SMN2PKM
SCHEMBL1737398 0.86 NPC1 (0.37) KDM4ETP53ALDH1A1SMN1; SMN2GAA
SCHEMBL1737569 0.86 PKM (0.39) KDM4EALDH1A1SMN1; SMN2PKMGAA
SCHEMBL1739242 0.85 KDM4E (0.35) KDM4EALDH1A1FFAR1MAPK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed
EP-1784404-A4 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2009-09-09 EP claimed
JP-2008511621-A 2008-04-17 JP claimed
EP-1784404-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Yuhan Corporation (KR) 2007-05-16 EP claimed
WO-2006025716-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 WO claimed