Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 17/20 | 0.72 |
| ▸ | DBF4 | Q9UBU7 | 17/20 | 0.72 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.72 |
| ▸ | CDK2 | P24941 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17374857 | 0.87 | CDC7 (0.55) | CDC7DBF4CCNE1CDK2KDM4E | |
| SCHEMBL17374913 | 0.86 | CDC7 (0.57) | CDC7DBF4CCNE1CDK2KDM4E | |
| SCHEMBL17374798 | 0.85 | CDC7 (0.53) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL17374792 | 0.85 | CDC7 (0.56) | CDC7DBF4CCNE1CDK2KDM4E | |
| SCHEMBL17374876 | 0.84 | CYP1A2 (0.56) | CDC7DBF4CCNE1CDK2KDM4E | |
| SCHEMBL8324969 | 0.84 | CDC7 (1.00) | CDC7DBF4CCNE1CDK2 | |
| SCHEMBL17374889 | 0.83 | CDC7 (0.51) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL17374874 | 0.81 | CDC7 (0.68) | CDC7DBF4CCNE1CDK2KDM4E | |
| SCHEMBL17374873 | 0.81 | RAB9A (0.55) | CDC7DBF4CCNE1CDK2ALDH1A1 | |
| SCHEMBL17374850 | 0.80 | TRPM8 (0.54) | CDC7DBF4CCNE1CDK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046662-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2021-06-29 | — | — | US | disclosed |
| CN-106660975-B | 2-aryl-4-hydroxy-1, 3-thiazole derivatives as TRPM 8-inhibitors for the treatment of neuralgia, pain, COPD and asthma | 东佩制药股份公司 | 2019-12-31 | — | — | CN | disclosed |
| US-20190106395-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-04-11 | — | — | US | disclosed |
| EP-3157918-B1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA. | DOMPE FARM SPA (IT) | 2019-03-27 | — | — | EP | disclosed |
| US-10196368-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-02-05 | — | — | US | disclosed |
| US-20170190678-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2017-07-06 | — | — | US | disclosed |
| EP-3157918-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | Dompé farmaceutici S.p.A. (IT) | 2017-04-26 | — | — | EP | disclosed |
| WO-2015197640-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | DOMPE' FARMACEUTICI S.P.A. (IT) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106395-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | TRPM8, TRPV1, TRPM7 | CDC7 2505/4885DBF4 3932/4885CCNE1 4324/4885 |
| US-20170190678-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | TRPM8, TRPV1, TRPM7 | CDC7 2505/4885DBF4 3932/4885CCNE1 4324/4885 |
| US-11046662-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | TRPM8, TRPV1, TRPM7 | CDC7 2481/4885DBF4 3899/4885CCNE1 4090/4885 |
| US-10196368-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | TRPM8, TRPV1, TRPM7 | CDC7 2505/4885DBF4 3932/4885CCNE1 4324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.