SCHEMBL17375296

SCHEMBL17375296

c1ccc(/N=N/N2CCCCC2)cc1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.62
NPC1 O15118 6/20 0.62
SMN1; SMN2 Q16637 5/20 0.62
GAA P10253 2/20 0.62
HTT P42858 2/20 0.62
ALDH1A1 P00352 2/20 0.62
MAPT P10636 7/20 0.60
CYP1A1 P04798 2/20 0.43
CYP1B1 Q16678 2/20 0.43
LMNA P02545 1/20 0.41
KMT2A Q03164 1/20 0.41
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
KCNA5 P22460 1/20 0.38
CYP2C19 P33261 1/20 0.38
KCNH2 Q12809 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17375298 1.00 RAB9A (0.62) RAB9ANPC1SMN1; SMN2GAAHTT
SCHEMBL22390775 1.00 RAB9A (0.62) RAB9ANPC1SMN1; SMN2GAAHTT
SCHEMBL22390777 1.00 RAB9A (0.62) RAB9ANPC1SMN1; SMN2GAAHTT
SCHEMBL6093254 0.98 MAPT (0.61) RAB9ANPC1SMN1; SMN2GAAHTT
SCHEMBL6093250 0.98 MAPT (0.61) RAB9ANPC1SMN1; SMN2GAAHTT
SCHEMBL13591514 0.85 NPC1 (0.57) RAB9ANPC1SMN1; SMN2GAAHTT
Iodide SCHEMBL27408 0.82 RAB9A (0.54) RAB9ANPC1SMN1; SMN2GAAHTT
SCHEMBL14709063 0.81 SIGMAR1 (0.47) RAB9ANPC1SMN1; SMN2GAAHTT
SCHEMBL28551727 0.79 NPC1 (0.59) RAB9ANPC1SMN1; SMN2GAAHTT
SCHEMBL11980120 0.79 NPC1 (0.59) RAB9ANPC1SMN1; SMN2GAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240254284-A1 UNSATURATED CYCLIC ANHYDRIDE END CAPPED POLYIMIDES AND POLYAMIC ACIDS AND PHOTOSENSITIVE COMPOSITIONS THEREOF PROMERUS, LLC (US) 2024-08-01 US claimed
US-20200283580-A1 UNSATURATED CYCLIC ANHYDRIDE END CAPPED POLYIMIDES AND POLYAMIC ACIDS AND PHOTOSENSITIVE COMPOSITIONS THEREOF PROMERUS, LLC (US) 2020-09-10 US claimed
US-12180385-B2 Shelf life stable and improved mass polymerizable polycyclic-olefinic compositions PROMERYS, LLC (US) 2024-12-31 US disclosed
US-20240254284-A1 UNSATURATED CYCLIC ANHYDRIDE END CAPPED POLYIMIDES AND POLYAMIC ACIDS AND PHOTOSENSITIVE COMPOSITIONS THEREOF PROMERUS, LLC (US) 2024-08-01 US disclosed
US-11845880-B2 Polycyclic-olefinic compositions for low-loss films having improved thermal properties PROMERUS, LLC (US) 2023-12-19 US disclosed
WO-2022256738-A1 BENCH-STABLE TRIAZENE COMPOSITIONS FOR PROTEIN MODIFICATION ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2022-12-08 WO disclosed
US-20220135831-A1 POLYCYCLIC-OLEFINIC COMPOSITIONS FOR LOW-LOSS FILMS HAVING IMPROVED THERMAL PROPERTIES PROMERUS, LLC (US) 2022-05-05 US disclosed
US-20220135832-A1 SHELF LIFE STABLE AND IMPROVED MASS POLYMERIZABLE POLYCYCLIC-OLEFINIC COMPOSITIONS PROMERUS, LLC (US) 2022-05-05 US disclosed
US-20200283580-A1 UNSATURATED CYCLIC ANHYDRIDE END CAPPED POLYIMIDES AND POLYAMIC ACIDS AND PHOTOSENSITIVE COMPOSITIONS THEREOF PROMERUS, LLC (US) 2020-09-10 US disclosed
US-10221198-B2 Preparation and medical use of triazenes ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2019-03-05 US disclosed
US-10221198-B2 Preparation and medical use of triazenes ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2019-03-05 US disclosed
US-20170158714-A1 Preparation and Medical Use of Triazenes ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2017-06-08 US disclosed
US-20170158714-A1 Preparation and Medical Use of Triazenes ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2017-06-08 US disclosed
US-20170158714-A1 Preparation and Medical Use of Triazenes ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2017-06-08 US disclosed
WO-2015197096-A1 PREPARATION AND MEDICAL USE OF TRIAZENES ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2015-12-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10221198-B2 Preparation and medical use of triazenes TBXA2R, XPO5, HIF1AN RAB9A 2412/4885NPC1 1033/4885SMN1; SMN2 4003/4885
US-20170158714-A1 Preparation and Medical Use of Triazenes TBXA2R, XPO5, HIF1AN RAB9A 2412/4885NPC1 1033/4885SMN1; SMN2 4003/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.