Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mandelic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mandelic Acid SCHEMBL20523297 | 0.95 | LMNA (0.62) | LMNAMAPK1SRCCES2CES1 | |
| Mandelic Acid SCHEMBL4847480 | 0.88 | LMNA (0.82) | LMNAMAPK1SRCCES2CES1 | |
| Mandelic Acid SCHEMBL2770258 | 0.84 | LMNA (0.75) | LMNAMAPK1SRCCES2CES1 | |
| Mandelic Acid SCHEMBL16499234 | 0.84 | LMNA (0.62) | LMNAMAPK1SRCCES2CES1 | |
| Mandelic Acid SCHEMBL5313046 | 0.83 | LMNA (1.00) | LMNAMAPK1SRCCES2CES1 | |
| Mandelic Acid SCHEMBL21647917 | 0.83 | LMNA (1.00) | LMNAMAPK1SRCCES2CES1 | |
| Mandelic Acid SCHEMBL165161 | 0.83 | LMNA (1.00) | LMNAMAPK1SRCCES2CES1 | |
| Mandelic Acid SCHEMBL255601 | 0.83 | LMNA (1.00) | LMNAMAPK1SRCCES2CES1 | |
| Mandelic Acid SCHEMBL29777368 | 0.83 | LMNA (1.00) | LMNAMAPK1SRCCES2CES1 | |
| Mandelic Acid SCHEMBL1050 | 0.83 | LMNA (1.00) | LMNAMAPK1SRCCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132216-B1 | NOVEL NUCLEOSIDE ANALOGS FOR TREATMENT OF VIRAL INFECTIONS | NOVARTIS PHARMA AG (CH) | 2011-11-16 | — | — | EP | disclosed |
| WO-2011131167-A2 | BISTABLE MAGNETIC ACTUATOR | JOHNSON ELECTRIC DRESDEN GMBH (DE) | 2011-10-27 | — | — | WO | disclosed |
| EP-2132216-A1 | NOVEL NUCLEOSIDE ANALOGS FOR TREATMENT OF VIRAL INFECTIONS | Novartis Pharma AG. (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008095993-A1 | NOVEL NUCLEOSIDE ANALOGS FOR TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2008-08-14 | — | — | WO | disclosed |