Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1737881 | 1.00 | HTR6 (0.36) | HTR6MAPK7NR1H2NR1H3LRRK2 | |
| SCHEMBL1737882 | 1.00 | HTR6 (0.36) | HTR6MAPK7NR1H2NR1H3LRRK2 | |
| SCHEMBL1737851 | 0.92 | DPP4 (0.38) | HTR6MAPK7LRRK2ROCK2ALDH1A1 | |
| SCHEMBL1738502 | 0.92 | DPP4 (0.38) | HTR6MAPK7LRRK2ROCK2ALDH1A1 | |
| SCHEMBL1738798 | 0.92 | DPP4 (0.38) | HTR6MAPK7LRRK2ROCK2ALDH1A1 | |
| SCHEMBL1737782 | 0.87 | DPP4 (0.37) | MAPK7LRRK2ALDH1A1L3MBTL1DPP4 | |
| SCHEMBL1738829 | 0.87 | DPP4 (0.37) | MAPK7LRRK2ALDH1A1L3MBTL1DPP4 | |
| SCHEMBL1737221 | 0.87 | DPP4 (0.37) | MAPK7LRRK2ALDH1A1L3MBTL1DPP4 | |
| SCHEMBL1737249 | 0.82 | ALDH1A1 (0.40) | HTR6MAPK7LRRK2ROCK2HSD11B1 | |
| SCHEMBL1737246 | 0.82 | ALDH1A1 (0.40) | HTR6MAPK7LRRK2ROCK2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727794-B1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PROD INC (US) | 2011-11-16 | — | — | EP | claimed |
| US-20110263484-A1 | SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME | ZYMOGENETICS, INC. | 2011-10-27 | — | — | US | claimed |