Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22299027 | 0.95 | CYP2C19 (0.44) | CYP2C19ALDH1A1MAPK1L3MBTL1CDC25B | |
| SCHEMBL13333203 | 0.86 | CYP2C19 (0.46) | CYP2C19ALDH1A1MAPK1L3MBTL1PPARG | |
| Cpi 613 SCHEMBL1062218 | 0.84 | CYP2C19 (0.59) | CYP2C19ALDH1A1MAPK1LMNAHPGD | |
| Cpi 613 SCHEMBL13333201 | 0.84 | CYP2C19 (0.59) | CYP2C19ALDH1A1MAPK1LMNAHPGD | |
| SCHEMBL20819171 | 0.84 | PPARG (0.42) | CYP2C19ALDH1A1EPHX2PPARAPPARG | |
| SCHEMBL20819168 | 0.84 | PPARG (0.42) | CYP2C19ALDH1A1EPHX2PPARAPPARG | |
| SCHEMBL22912360 | 0.84 | CYP2C19 (0.46) | CYP2C19ALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL22299081 | 0.83 | CYP2C19 (0.58) | CYP2C19ALDH1A1MAPK1LMNAHPGD | |
| SCHEMBL17381514 | 0.83 | CYP2C19 (0.58) | CYP2C19ALDH1A1MAPK1LMNAHPGD | |
| SCHEMBL13333202 | 0.83 | CYP2C19 (0.50) | CYP2C19ALDH1A1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189033-B1 | PHARMACEUTICAL COMPOUNDS | RAFAEL PHARMACEUTICALS INC (US) | 2020-08-05 | — | — | EP | disclosed |
| US-10450337-B2 | Pharmaceutical compounds | RAFAEL PHARMACEUTICALS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-20170218003-A1 | PHARMACEUTICAL COMPOUNDS | RAFAEL PHARMACEUTICALS, INC. | 2017-08-03 | — | — | US | disclosed |
| US-20170218003-A1 | PHARMACEUTICAL COMPOUNDS | RAFAEL PHARMACEUTICALS, INC. | 2017-08-03 | — | — | US | disclosed |
| WO-2015195070-A1 | PHARMACEUTICAL COMPOUNDS | SHORR ROBERT (US) | 2015-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170218003-A1 | PHARMACEUTICAL COMPOUNDS | SLC27A1, LIPA, ALOX12 | CYP2C19 1175/4885ALDH1A1 761/4885MAPK1 3590/4885 |
| US-10450337-B2 | Pharmaceutical compounds | SLC27A1, LIPA, ALOX12 | CYP2C19 1175/4885ALDH1A1 761/4885MAPK1 3590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.