Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 16/20 | 0.39 |
| ▸ | JAK1 | P23458 | 16/20 | 0.39 |
| ▸ | TYK2 | P29597 | 16/20 | 0.39 |
| ▸ | JAK3 | P52333 | 16/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12460156 | 1.00 | NOS1 (0.39) | NOS1JAK2JAK1TYK2JAK3 | |
| SCHEMBL15986683 | 1.00 | NOS1 (0.39) | NOS1JAK2JAK1TYK2JAK3 | |
| SCHEMBL12460187 | 0.81 | JAK2 (0.39) | NOS1JAK2JAK1TYK2JAK3 | |
| SCHEMBL16478707 | 0.81 | NOS1 (0.41) | NOS1JAK2JAK1TYK2JAK3 | |
| SCHEMBL12179239 | 0.81 | NOS1 (0.41) | NOS1JAK2JAK1TYK2JAK3 | |
| SCHEMBL16478706 | 0.81 | NOS1 (0.41) | NOS1JAK2JAK1TYK2JAK3 | |
| SCHEMBL16940784 | 0.81 | HPGD (0.43) | NOS1JAK2JAK1TYK2JAK3 | |
| SCHEMBL16940762 | 0.81 | HPGD (0.43) | NOS1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13165391 | 0.80 | JAK2 (0.40) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL19321626 | 0.80 | JAK2 (0.40) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3157929-B1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | ARES TRADING SA (CH) | 2023-12-13 | — | — | EP | disclosed |
| US-20170253605-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | TOCOPHERX, INC. (US) | 2017-09-07 | — | — | US | disclosed |
| US-9433622-B2 | Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-06 | — | — | US | disclosed |
| US-20160000784-A1 | PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS | DOMAINEX LIMITED (GB) | 2016-01-07 | — | — | US | disclosed |
| WO-2015196759-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | TOCOPHERX, INC. (US) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000784-A1 | PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS | TBK1, TBKBP1, TYMS | NOS1 3043/4885JAK2 608/4885JAK1 112/4885 |
| US-20170253605-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | FSHR, GNRHR, LHCGR | NOS1 4155/4885JAK2 1967/4885JAK1 2223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.