Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1738796 | 1.00 | ROCK2 (0.43) | ROCK2FPR2HTR2CDRD2DRD3 | |
| SCHEMBL1738546 | 1.00 | ROCK2 (0.43) | ROCK2FPR2HTR2CDRD2DRD3 | |
| SCHEMBL1738549 | 1.00 | ROCK2 (0.43) | ROCK2FPR2HTR2CDRD2DRD3 | |
| SCHEMBL1737760 | 0.90 | ROCK2 (0.41) | ROCK2FPR2HTR2CDRD2DRD3 | |
| SCHEMBL1737717 | 0.90 | ROCK2 (0.41) | ROCK2FPR2HTR2CDRD2DRD3 | |
| SCHEMBL1737713 | 0.90 | ROCK2 (0.41) | ROCK2FPR2HTR2CDRD2DRD3 | |
| SCHEMBL1738622 | 0.89 | HTR1A (0.45) | ROCK2HTR2CDRD2DRD3HTR1A | |
| SCHEMBL5160777 | 0.88 | FPR2 (0.46) | ROCK2FPR2HTR2CDRD2DRD3 | |
| SCHEMBL5158579 | 0.88 | FPR2 (0.46) | ROCK2FPR2HTR2CDRD2DRD3 | |
| SCHEMBL5158577 | 0.88 | FPR2 (0.46) | ROCK2FPR2HTR2CDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727794-B1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PROD INC (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110263484-A1 | SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME | ZYMOGENETICS, INC. | 2011-10-27 | — | — | US | disclosed |
| EP-1727794-A1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | Pfizer Products Incorporated (US) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005090300-A1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2005-09-29 | — | — | WO | disclosed |