SCHEMBL17388809

SCHEMBL17388809

C#CCCc1nnc(C(=O)OCC)s1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.43
ALDH1A1 P00352 4/20 0.41
NPSR1 Q6W5P4 1/20 0.40
POLB P06746 2/20 0.40
CYP2C9 P11712 1/20 0.39
HPGD P15428 2/20 0.38
HSD17B10 Q99714 2/20 0.38
KDM4E B2RXH2 1/20 0.38
USP2 O75604 1/20 0.38
GAA P10253 2/20 0.37
MAPT P10636 2/20 0.37
G6PD P11413 1/20 0.37
AKT1 P31749 1/20 0.37
IRS1 P35568 1/20 0.37
GAB1 Q13480 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
TSHR P16473 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17288767 0.92 ALDH1A1 (0.42) RECQLALDH1A1NPSR1POLBCYP2C9
SCHEMBL31497061 0.83 NPSR1 (0.51) RECQLALDH1A1NPSR1POLBCYP2C9
SCHEMBL19558977 0.83 RECQL (0.56) RECQLALDH1A1NPSR1POLBCYP2C9
SCHEMBL17079289 0.80 POLB (0.46) RECQLALDH1A1NPSR1POLBCYP2C9
SCHEMBL15945408 0.79 GAA (0.50) RECQLALDH1A1NPSR1POLBHPGD
SCHEMBL17402505 0.79 NPSR1 (0.58) RECQLALDH1A1NPSR1POLBCYP2C9
Hydrochloric Acid SCHEMBL17871640 0.79 POLB (0.44) RECQLALDH1A1NPSR1POLBCYP2C9
SCHEMBL13477788 0.78 GAA (0.44) RECQLALDH1A1POLBHPGDHSD17B10
SCHEMBL17390707 0.78 NPSR1 (0.47) RECQLALDH1A1NPSR1POLBCYP2C9
SCHEMBL17396790 0.77 RECQL (0.40) RECQLALDH1A1NPSR1POLBCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240360121-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-10-31 US disclosed
US-11958849-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-04-16 US disclosed
US-20230124815-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-04-20 US disclosed
US-20230124815-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-04-20 US disclosed
US-11370786-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-06-28 US disclosed
US-11370786-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-06-28 US disclosed
CN-107074805-B GLS1 inhibitors for the treatment of disease 德州大学系统董事会 2021-02-26 CN disclosed
US-20200407353-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2020-12-31 US disclosed
US-20200407353-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2020-12-31 US disclosed
US-10766892-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-09-08 US disclosed
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-14 US disclosed
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-14 US disclosed
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-14 US disclosed
WO-2016004404-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004404-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004413-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004413-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
US-20160002248-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 US disclosed
US-20160002248-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 US disclosed
US-20160002248-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160002248-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 RECQL 1850/4885ALDH1A1 882/4885NPSR1 2383/4885
US-20240360121-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 RECQL 1850/4885ALDH1A1 882/4885NPSR1 2383/4885
US-20230124815-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 RECQL 1850/4885ALDH1A1 882/4885NPSR1 2383/4885
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 RECQL 1850/4885ALDH1A1 882/4885NPSR1 2383/4885
US-10766892-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLG1 RECQL 1850/4885ALDH1A1 882/4885NPSR1 2383/4885
US-11370786-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLB1 RECQL 2458/4885ALDH1A1 766/4885NPSR1 2582/4885
US-11958849-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLG1 RECQL 1850/4885ALDH1A1 882/4885NPSR1 2383/4885
US-20200407353-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 RECQL 1850/4885ALDH1A1 882/4885NPSR1 2383/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.