SCHEMBL1739006

SCHEMBL1739006

C=CCn1c(C)c(C)c2ccnc(-c3ccc(SC)cc3)c21

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.36
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
KDM4E B2RXH2 3/20 0.31
NPSR1 Q6W5P4 1/20 0.31
MAPT P10636 3/20 0.31
ALDH1A1 P00352 2/20 0.31
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.31
KMT2A Q03164 1/20 0.31
LMNA P02545 1/20 0.31
HPGD P15428 1/20 0.31
MAPK13 O15264 3/20 0.31
MAPK12 P53778 3/20 0.31
MAPK11 Q15759 3/20 0.31
MAPK14 Q16539 3/20 0.31
GCGR P47871 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1736277 0.99 RAB9A (0.36) RAB9ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL3842082 0.90 KDM4E (0.38) RAB9ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL1735921 0.88 NPSR1 (0.41) RAB9ACYP1A2CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL1736632 0.86 NPSR1 (0.40) RAB9ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL1735899 0.86 KDM4E (0.33) KDM4EMAPTALDH1A1GAA
SCHEMBL1737486 0.85 CACNA1B (0.34) RAB9ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL1738539 0.85 ALDH1A1 (0.41) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL1739802 0.85 MAPT (0.42) RAB9ACYP1A2CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL1737493 0.85 KDM4E (0.32) KDM4EMAPTALDH1A1GAA
SCHEMBL1739189 0.85 CYP17A1 (0.34) RAB9AKDM4EMAPTALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed