Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 4/20 | 0.42 |
| ▸ | NAAA | Q02083 | 6/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20137677 | 0.88 | EPHX2 (0.55) | EPHX2GRIN1GRIN2BCYP2C9CHRM2 | |
| SCHEMBL20137678 | 0.88 | EPHX2 (0.55) | EPHX2GRIN1GRIN2BCYP2C9CHRM2 | |
| SCHEMBL5266581 | 0.85 | EPHX2 (0.60) | EPHX2GRIN1GRIN2BCYP2C9CHRM2 | |
| SCHEMBL20958357 | 0.80 | NAAA (0.53) | EPHX2GRIN1GRIN2BCYP2C9CHRM2 | |
| SCHEMBL2997553 | 0.80 | GPR119 (0.52) | EPHX2GRIN1GRIN2BCYP2C9NAAA | |
| SCHEMBL1740359 | 0.78 | EPHX2 (0.50) | EPHX2FAAH | |
| SCHEMBL14874081 | 0.77 | CHRM2 (0.49) | EPHX2GRIN1GRIN2BCYP2C9CHRM2 | |
| SCHEMBL20958461 | 0.77 | NAAA (0.51) | EPHX2GRIN1GRIN2BCYP2C9CHRM2 | |
| SCHEMBL20958463 | 0.77 | NAAA (0.51) | EPHX2GRIN1GRIN2BCYP2C9CHRM2 | |
| SCHEMBL20958462 | 0.77 | NAAA (0.51) | EPHX2GRIN1GRIN2BCYP2C9CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389382-A1 | Amino-heterocyclic compounds used as pde9 inhibitors | Pfizer Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-8041687-B2 | Dynamic generation of XML Schema for backend driven data validation | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2010084438-A1 | AMINO-HETEROCYCLIC COMPOUNDS USED AS PDE9 INHIBITORS | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |