Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NEK1 | Q96PY6 | 4/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397111 | 0.87 | PIK3CD (0.35) | PIK3CDPIK3CBPIK3CATAAR1 | |
| SCHEMBL17397079 | 0.85 | PIK3CD (0.42) | PIK3CDPIK3CBTP53PIK3CATAAR1 | |
| SCHEMBL17397135 | 0.79 | PIK3CD (0.42) | PIK3CDNPC1RAB9ANEK1PIK3CB | |
| SCHEMBL17397072 | 0.78 | TAAR1 (0.40) | PIK3CDTAAR1GRIN2BDPP4 | |
| SCHEMBL17397312 | 0.76 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17397082 | 0.70 | PIK3CD (0.42) | PIK3CDPIK3CBTP53CD274PIK3CA | |
| SCHEMBL17397113 | 0.65 | PIK3CD (0.45) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17397271 | 0.65 | TAAR1 (0.42) | PIK3CDPIK3CBPIK3CATAAR1 | |
| SCHEMBL17397110 | 0.63 | PIK3CD (0.43) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17397202 | 0.63 | PIK3CA (0.40) | PIK3CDPIK3CBPIK3CATAAR1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |