Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397174 | 0.92 | PIK3CD (0.42) | PIK3CAPIK3CDPIK3CBTAAR1HTR6 | |
| SCHEMBL17397176 | 0.91 | PIK3CD (0.41) | PIK3CAMAOBPIK3CDPIK3CBTAAR1 | |
| SCHEMBL17397271 | 0.87 | TAAR1 (0.42) | PIK3CAPIK3CDPIK3CBTAAR1 | |
| SCHEMBL17397294 | 0.85 | PIK3CD (0.46) | PIK3CAPIK3CDPIK3CBTAAR1 | |
| SCHEMBL18989093 | 0.81 | HTR2A (0.33) | PIK3CAPIK3CDPIK3CBTAAR1HTR6 | |
| SCHEMBL17397122 | 0.80 | TAAR1 (0.37) | PIK3CAPIK3CDPIK3CBTAAR1MPO | |
| SCHEMBL17397287 | 0.80 | PIM1 (0.41) | — | |
| SCHEMBL17397173 | 0.79 | PIK3CD (0.41) | PIK3CAPIK3CDPIK3CB | |
| SCHEMBL18989250 | 0.78 | MAOB (0.37) | MAOBPIK3CDTAAR1HTR6HTR2A | |
| SCHEMBL18989286 | 0.75 | PIK3CD (0.40) | PIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |