Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397122 | 0.93 | TAAR1 (0.37) | TAAR1PIK3CDPIK3CAPIK3CBTGFBR1 | |
| SCHEMBL17397174 | 0.90 | PIK3CD (0.42) | TAAR1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL17397176 | 0.89 | PIK3CD (0.41) | TAAR1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL17397202 | 0.87 | PIK3CA (0.40) | TAAR1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL17397287 | 0.85 | PIM1 (0.41) | — | |
| SCHEMBL17397294 | 0.83 | PIK3CD (0.46) | TAAR1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL19006238 | 0.80 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL17397072 | 0.79 | TAAR1 (0.40) | TAAR1PIK3CDTGFBR1DHODH | |
| SCHEMBL17397173 | 0.78 | PIK3CD (0.41) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18989093 | 0.77 | HTR2A (0.33) | TAAR1PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |