Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | GRK6 | P43250 | 3/20 | 0.35 |
| ▸ | IGF1R | P08069 | 6/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398011 | 0.84 | HPGD (0.42) | JAK2JAK3GRK6IGF1RCDK7 | |
| SCHEMBL17397977 | 0.82 | JAK1 (0.39) | JAK2JAK1TYK2JAK3GRK6 | |
| SCHEMBL17398060 | 0.82 | AURKA (0.46) | JAK2JAK3IGF1RCDK7 | |
| SCHEMBL17398086 | 0.80 | IGF1R (0.45) | IGF1R | |
| SCHEMBL17398037 | 0.80 | IGF1R (0.45) | IGF1R | |
| SCHEMBL17397942 | 0.80 | IGF1R (0.44) | IGF1R | |
| SCHEMBL17398061 | 0.80 | LMNA (0.34) | GRK6IGF1RCDK7HTR6 | |
| SCHEMBL17398018 | 0.78 | MAPT (0.44) | — | |
| SCHEMBL17397900 | 0.76 | IGF1R (0.39) | IGF1R | |
| SCHEMBL17398088 | 0.74 | CDK2 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |