Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397956 | 0.82 | ITK (0.64) | ALDH1A1ITKLMNAMAPTSMN1; SMN2 | |
| SCHEMBL17397919 | 0.81 | ITK (0.63) | ALDH1A1ITKLMNAMAPTSMN1; SMN2 | |
| SCHEMBL17398075 | 0.81 | ITK (0.42) | ALDH1A1ITKLMNAMAPTSMN1; SMN2 | |
| SCHEMBL17413473 | 0.79 | ITK (0.44) | ALDH1A1GAAITKLMNAMAPT | |
| SCHEMBL17397915 | 0.77 | SMN1; SMN2 (0.48) | ALDH1A1GAAITKLMNAMAPT | |
| SCHEMBL17398063 | 0.77 | SMN1; SMN2 (0.46) | ALDH1A1GAAITKLMNAMAPT | |
| SCHEMBL17397936 | 0.77 | ITK (0.41) | ALDH1A1ITKLMNAMAPTSMN1; SMN2 | |
| SCHEMBL17398012 | 0.76 | ALDH1A1 (0.48) | ALDH1A1GAALMNAMAPTSMN1; SMN2 | |
| SCHEMBL17398019 | 0.76 | ITK (0.40) | ALDH1A1GAAITKKMT2AMEN1 | |
| SCHEMBL17397908 | 0.75 | ITK (0.41) | ALDH1A1ITKLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |