Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 4/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398010 | 0.82 | ALDH1A1 (0.48) | ITKSMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL17397925 | 0.81 | KDR (0.49) | ITKKDRSRCLCK | |
| SCHEMBL17398075 | 0.80 | ITK (0.42) | ITKSMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL17397980 | 0.79 | ALDH1A1 (0.44) | ITKKDRLYNSRCBTK | |
| SCHEMBL17413371 | 0.78 | ITK (1.00) | ITKKDRLYNSRCBTK | |
| SCHEMBL17397919 | 0.78 | ITK (0.63) | ITKSMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL17413426 | 0.78 | ITK (0.78) | ITKKDRLYNSRCBTK | |
| SCHEMBL17397958 | 0.77 | ITK (0.46) | ITKKDRGSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL17413552 | 0.76 | KDR (0.49) | ITKKDRLYNSRCBTK | |
| SCHEMBL17413432 | 0.76 | ITK (0.73) | ITKKDRLYNSRCBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |