Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398010 | 0.81 | ALDH1A1 (0.48) | ITKHTTL3MBTL1LMNAMAPT | |
| SCHEMBL17397956 | 0.80 | ITK (0.64) | ITKHTTL3MBTL1LMNAMAPT | |
| SCHEMBL17413398 | 0.79 | ITK (0.42) | ITKPIK3CAPIK3C3SCN9AALDH1A1 | |
| SCHEMBL17397919 | 0.76 | ITK (0.63) | ITKHTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL17398058 | 0.75 | AURKA (0.49) | ITKPIK3C3 | |
| SCHEMBL17397980 | 0.75 | ALDH1A1 (0.44) | ITKHTTL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL17397933 | 0.74 | ITK (0.41) | ITKHTTL3MBTL1LMNAMAPT | |
| SCHEMBL17398027 | 0.74 | KDM4E (0.50) | ITKHTTLMNASMN1; SMN2KMT2A | |
| SCHEMBL17397915 | 0.73 | SMN1; SMN2 (0.48) | ITKHTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL17398063 | 0.73 | SMN1; SMN2 (0.46) | ITKHTTLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |