Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 11/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15590888 | 0.83 | L3MBTL1 (0.49) | ADRB3ADRB1ADRB2SLC2A1MEN1 | |
| SCHEMBL16788643 | 0.83 | L3MBTL1 (0.49) | ADRB3ADRB1ADRB2SLC2A1MEN1 | |
| SCHEMBL14402491 | 0.80 | ADRB1 (0.48) | ADRB3ADRB1ADRB2SLC2A1IDO1 | |
| SCHEMBL13849930 | 0.80 | ADRB1 (0.48) | ADRB3ADRB1ADRB2SLC2A1IDO1 | |
| SCHEMBL13849942 | 0.80 | ADRB1 (0.48) | ADRB3ADRB1ADRB2SLC2A1IDO1 | |
| SCHEMBL6690481 | 0.80 | ADRB1 (0.48) | ADRB3ADRB1ADRB2SLC2A1IDO1 | |
| SCHEMBL13950144 | 0.79 | RIPK1 (0.53) | — | |
| SCHEMBL3156406 | 0.79 | IDO1 (0.48) | ADRB3ADRB1ADRB2SLC2A1MEN1 | |
| SCHEMBL282798 | 0.79 | IDO1 (0.48) | ADRB3ADRB1ADRB2SLC2A1MEN1 | |
| SCHEMBL281883 | 0.79 | IDO1 (0.48) | ADRB3ADRB1ADRB2SLC2A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164130-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016004136-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | DUFFEY MATTHEW O (US) | 2016-01-07 | — | — | WO | disclosed |