Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1738839 | 1.00 | FPR2 (0.36) | FPR2NCF1KAT2BSIGMAR1KDM4E | |
| SCHEMBL1738667 | 1.00 | FPR2 (0.36) | FPR2NCF1KAT2BSIGMAR1KDM4E | |
| SCHEMBL1738815 | 0.93 | NCF1 (0.38) | FPR2NCF1SIGMAR1ALDH1A1KMT2A | |
| SCHEMBL1738368 | 0.93 | NCF1 (0.38) | FPR2NCF1SIGMAR1ALDH1A1KMT2A | |
| SCHEMBL1737661 | 0.93 | NCF1 (0.38) | FPR2NCF1SIGMAR1ALDH1A1KMT2A | |
| SCHEMBL1738835 | 0.88 | ROCK2 (0.39) | FPR2NCF1SIGMAR1KMT2AROCK2 | |
| SCHEMBL1737234 | 0.88 | ROCK2 (0.39) | FPR2NCF1SIGMAR1KMT2AROCK2 | |
| SCHEMBL1738621 | 0.88 | ROCK2 (0.39) | FPR2NCF1SIGMAR1KMT2AROCK2 | |
| SCHEMBL1737818 | 0.88 | ROCK2 (0.39) | FPR2NCF1SIGMAR1KMT2AROCK2 | |
| SCHEMBL1738872 | 0.88 | ROCK2 (0.39) | FPR2NCF1SIGMAR1KMT2AROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727794-B1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PROD INC (US) | 2011-11-16 | — | — | EP | claimed |
| US-20110263484-A1 | SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME | ZYMOGENETICS, INC. | 2011-10-27 | — | — | US | claimed |
| US-7479559-B2 | 3-[-2-(Piperazin-1-yl)benzyl]pyrrolidin-2-one derivatives; antidepressants, anxiolytic agents; obsessive compulsive disorder, psychological disorders, phobias; 5-HT1 agonist or antagonists; side effect reduction, in particular cardiac QTc prolongation; hydrogenation | PFIZER INC. (US) | 2009-01-20 | — | — | US | claimed |