Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 8/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL176318 | 0.90 | DGAT1 (0.52) | DGAT1 | |
| SCHEMBL174155 | 0.89 | DGAT1 (0.51) | EPHX2DGAT1CNR1CA12CA1 | |
| SCHEMBL176202 | 0.88 | DGAT1 (0.41) | EPHX2DGAT1CNR1CA12CA1 | |
| SCHEMBL161756 | 0.84 | EPHX2 (0.42) | EPHX2DGAT1CNR1CA12CA1 | |
| SCHEMBL161985 | 0.81 | EPHX2 (0.41) | EPHX2DGAT1CNR1CA12CA1 | |
| SCHEMBL161219 | 0.74 | DGAT1 (0.54) | EPHX2DGAT1CA12CA1CA2 | |
| SCHEMBL164213 | 0.73 | EPHX2 (0.54) | EPHX2DGAT1CNR1 | |
| SCHEMBL161700 | 0.73 | DGAT1 (0.53) | EPHX2DGAT1CNR1CA12CA1 | |
| SCHEMBL161059 | 0.71 | CNR1 (0.42) | EPHX2DGAT1CNR1CA12CA1 | |
| SCHEMBL175829 | 0.70 | DGAT1 (0.50) | EPHX2DGAT1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |