Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174155 | 0.92 | DGAT1 (0.51) | DGAT1NTRK1KDR | |
| SCHEMBL174029 | 0.90 | EPHX2 (0.41) | DGAT1 | |
| SCHEMBL176202 | 0.87 | DGAT1 (0.41) | DGAT1KDRKMT2A | |
| SCHEMBL161219 | 0.85 | DGAT1 (0.54) | DGAT1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL175829 | 0.81 | DGAT1 (0.50) | DGAT1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL161700 | 0.76 | DGAT1 (0.53) | DGAT1NTRK1KMT2A | |
| SCHEMBL164213 | 0.74 | EPHX2 (0.54) | DGAT1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL161756 | 0.74 | EPHX2 (0.42) | DGAT1KMT2A | |
| SCHEMBL163047 | 0.73 | DGAT1 (0.51) | DGAT1KDRKMT2A | |
| SCHEMBL162546 | 0.73 | DGAT1 (0.49) | DGAT1SMN1; SMN2LMNAMAPTNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |