Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 9/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174155 | 0.88 | DGAT1 (0.51) | DGAT1CNR1KDRFLT3AURKA | |
| SCHEMBL174029 | 0.88 | EPHX2 (0.41) | DGAT1CNR1EPHX2CA12CA1 | |
| SCHEMBL176318 | 0.87 | DGAT1 (0.52) | DGAT1KMT2AKDR | |
| SCHEMBL161059 | 0.83 | CNR1 (0.42) | DGAT1KMT2ACNR1KDRFLT3 | |
| SCHEMBL175824 | 0.80 | EPHX2 (0.40) | DGAT1KMT2ACNR1KDRFLT3 | |
| SCHEMBL164213 | 0.75 | EPHX2 (0.54) | DGAT1KMT2ACNR1KDRFLT3 | |
| SCHEMBL163047 | 0.72 | DGAT1 (0.51) | DGAT1KMT2ACNR1KDREPHX2 | |
| SCHEMBL161700 | 0.72 | DGAT1 (0.53) | DGAT1KMT2ACNR1EPHX2NAMPT | |
| SCHEMBL162102 | 0.72 | EPHX2 (0.52) | DGAT1KMT2ACNR1KDREPHX2 | |
| SCHEMBL161756 | 0.71 | EPHX2 (0.42) | DGAT1KMT2ACNR1EPHX2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |