Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9938014 | 0.98 | OPRL1 (0.49) | OPRL1OPRK1OPRM1OPRD1MAOA | |
| SCHEMBL16600810 | 0.84 | GRIN2B (0.46) | OPRL1OPRK1OPRM1OPRD1MAOA | |
| SCHEMBL5509592 | 0.84 | SLC6A2 (0.47) | OPRL1OPRK1OPRM1OPRD1MAOA | |
| Hydrochloric Acid SCHEMBL18038811 | 0.83 | OPRL1 (0.47) | OPRL1OPRK1OPRM1OPRD1MAOA | |
| SCHEMBL20109496 | 0.81 | CYP2D6 (0.46) | OPRL1OPRK1OPRM1OPRD1MAOA | |
| Tert-Butyl Formate SCHEMBL28821595 | 0.81 | OPRL1 (0.38) | OPRL1OPRK1OPRM1OPRD1SLC6A2 | |
| SCHEMBL23343753 | 0.79 | OPRL1 (0.65) | OPRL1OPRK1OPRM1OPRD1MAOA | |
| SCHEMBL613290 | 0.79 | OPRL1 (0.51) | OPRL1OPRK1OPRM1OPRD1MAOA | |
| SCHEMBL24362269 | 0.79 | GRIN2D (0.41) | OPRL1OPRK1OPRM1OPRD1GRIN2B | |
| SCHEMBL27917951 | 0.79 | ALDH1A1 (0.39) | MAOAMAOBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113226356-B | Activation of pyruvate kinase R | 诺沃挪第克健康护理股份公司 | 2025-03-04 | — | — | CN | disclosed |
| US-12122778-B2 | Activating pyruvate kinase R | NOVO NORDISK HEALTH CARE AG (CH) | 2024-10-22 | — | — | US | disclosed |
| EP-3852791-B1 | ACTIVATING PYRUVATE KINASE R | NOVO NORDISK HEALTHCARE AG (CH) | 2024-07-03 | — | — | EP | disclosed |
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. | 2024-02-29 | — | — | US | disclosed |
| US-20230055923-A1 | ACTIVATING PYRUVATE KINASE R | NOVO NORDISK HEALTH CARE AG (CH) | 2023-02-23 | — | — | US | disclosed |
| US-20230055923-A1 | ACTIVATING PYRUVATE KINASE R | NOVO NORDISK HEALTH CARE AG (CH) | 2023-02-23 | — | — | US | disclosed |
| CN-113226356-A | Activating pyruvate kinase R | 福马治疗股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| EP-3852791-A1 | ACTIVATING PYRUVATE KINASE R | Forma Therapeutics, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020061255-A1 | ACTIVATING PYRUVATE KINASE R | FORMA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
| WO-2020061255-A1 | ACTIVATING PYRUVATE KINASE R | FORMA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
| US-8278295-B2 | Amino-heterocyclic compounds | PFIZER INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278295-B2 | Amino-heterocyclic compounds | PFIZER INC. (US) | 2012-10-02 | — | — | US | disclosed |
| CN-102292340-A | Amino-heterocyclic compounds used as PDE9 inhibitors | — | 2011-12-21 | — | — | CN | disclosed |
| EP-2389382-A1 | Amino-heterocyclic compounds used as pde9 inhibitors | Pfizer Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-8041687-B2 | Dynamic generation of XML Schema for backend driven data validation | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2010-07-29 | — | — | US | disclosed |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2010-07-29 | — | — | US | disclosed |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2010-07-29 | — | — | US | disclosed |
| WO-2010084438-A1 | AMINO-HETEROCYCLIC COMPOUNDS USED AS PDE9 INHIBITORS | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010084438-A1 | AMINO-HETEROCYCLIC COMPOUNDS USED AS PDE9 INHIBITORS | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230055923-A1 | ACTIVATING PYRUVATE KINASE R | PDK1, PDK2, PKLR | OPRL1 4439/4885OPRK1 2248/4885OPRM1 4484/4885 |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PDE9A, PDE2A, PDE10A | OPRL1 1769/4885OPRK1 1981/4885OPRM1 3328/4885 |
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | NAMPT, NNT, NAPRT | OPRL1 3059/4885OPRK1 3021/4885OPRM1 3418/4885 |
| US-12122778-B2 | Activating pyruvate kinase R | PDK1, PDK2, PKLR | OPRL1 4439/4885OPRK1 2248/4885OPRM1 4484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.