Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR5A | P47898 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732267 | 0.87 | NCF1 (0.46) | HTR1AHTR2ADRD2DRD4HTR2C | |
| SCHEMBL5611262 | 0.87 | NCF1 (0.46) | HTR1AHTR2ADRD2DRD4HTR2C | |
| SCHEMBL1737562 | 0.87 | NCF1 (0.46) | HTR1AHTR2ADRD2DRD4HTR2C | |
| SCHEMBL4474160 | 0.85 | CHRNA7 (0.39) | HTR1AHTR2ADRD2DRD4HTR2C | |
| SCHEMBL4480301 | 0.83 | NCF1 (0.54) | HTR1AHTR2ADRD2DRD4HTR2C | |
| SCHEMBL4475156 | 0.80 | PTGER3 (0.33) | HTR1DHTR1B | |
| SCHEMBL4477924 | 0.80 | NCF1 (0.47) | HTR1AHTR2ADRD2DRD4HTR2C | |
| SCHEMBL27686595 | 0.76 | — | — | |
| SCHEMBL31561598 | 0.74 | HTR1A (0.73) | HTR1ASLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL335802 | 0.74 | HTR1A (0.73) | HTR1ASLC6A2SLC6A4SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727794-B1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PROD INC (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110263484-A1 | SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME | ZYMOGENETICS, INC. | 2011-10-27 | — | — | US | disclosed |
| US-8012969-B2 | Radiopharmaceutical for positron emission tomography; imaging brain tissue; labeled serotonin type 1B (5HT1B) receptor ligands | GE HEALTHCARE LIMITED (GB) | 2011-09-06 | — | — | US | disclosed |
| US-8012969-B2 | Radiopharmaceutical for positron emission tomography; imaging brain tissue; labeled serotonin type 1B (5HT1B) receptor ligands | GE HEALTHCARE LIMITED (GB) | 2011-09-06 | — | — | US | disclosed |
| US-8012969-B2 | Radiopharmaceutical for positron emission tomography; imaging brain tissue; labeled serotonin type 1B (5HT1B) receptor ligands | GE HEALTHCARE LIMITED (GB) | 2011-09-06 | — | — | US | disclosed |
| EP-1836164-B1 | 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS | GE HEALTHCARE LTD (GB) | 2011-08-24 | — | — | EP | disclosed |
| EP-1836164-B1 | 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS | GE HEALTHCARE LTD (GB) | 2011-08-24 | — | — | EP | disclosed |
| US-7479559-B2 | 3-[-2-(Piperazin-1-yl)benzyl]pyrrolidin-2-one derivatives; antidepressants, anxiolytic agents; obsessive compulsive disorder, psychological disorders, phobias; 5-HT1 agonist or antagonists; side effect reduction, in particular cardiac QTc prolongation; hydrogenation | PFIZER INC. (US) | 2009-01-20 | — | — | US | disclosed |
| US-20080206137-A1 | 11C-Labeled Benzyl-Lactam Compounds and Their Use as Imaging Agents | GE HEALTHCARE LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
| US-20080206137-A1 | 11C-Labeled Benzyl-Lactam Compounds and Their Use as Imaging Agents | GE HEALTHCARE LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
| US-20080206137-A1 | 11C-Labeled Benzyl-Lactam Compounds and Their Use as Imaging Agents | GE HEALTHCARE LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
| EP-1836164-A1 | 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS | Pfizer Products Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| EP-1727794-A1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | Pfizer Products Incorporated (US) | 2006-12-06 | — | — | EP | disclosed |
| WO-2006075226-A1 | 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS | PFIZER PRODUCTS INC. (US) | 2006-07-20 | — | — | WO | disclosed |
| US-20050245521-A1 | Novel benayl(idene)-lactam derivatives | PFIZER INC. | 2005-11-03 | — | — | US | disclosed |
| WO-2005090300-A1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245521-A1 | Novel benayl(idene)-lactam derivatives | HTR1E, HTR1D, HTR1A | HTR1A 3/4885SLC6A2 355/4885SLC6A4 147/4885 |
| US-20080206137-A1 | 11C-Labeled Benzyl-Lactam Compounds and Their Use as Imaging Agents | TMEM14C, QPCT, PAICS | HTR1A 2353/4885SLC6A2 2057/4885SLC6A4 2437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.